Example of modeling a multiproduct biopharmaceutical facility.
Simplified section of a larger process flowsheet showing the typical
scheduling of fermentation with media prep. Fermentation is usually the
longest step of a bioprocess, and the first place that bottlenecks might
The schedule shows 2 identical processes that share a media prep tank.
Therefore the complete plant would contain 2 seed fermenters, and 2 main
fermenters, one set for each process. However those two main fermenters
are fed from the same media prep tank.
In this example there are no issues with the single shared tank as it
is not in use for an extended time, and can easily be cleaned and turned
around. However conflicts can easily arise in processes where there are
many tanks to be shared, or tanks are in use for extended periods.
The facility also includes a shared CIP (Clean-in-place) skid and a shared
SIP (Steam-in-place) skid. Again, in this example the CIP skid utilization
is low, and there are no conflicts, however even here one can observe
the bunching together of CIP operations. This is typical, and can become
problematic when many vessels are cleaned. Sometimes cleaning schedules
require manipulation to optimize and spread the CIP operations.
Select the images to display a larger image.
General Flowsheet for Process A and Process B
Equipment Occupancy Profiles for the Production Schedule
B-0 - Process A, batch 1 B-1 - Process A, batch
B-2 - Process B, batch 1 B-3 - Process B, batch 2