Process Simulation

​Scheduling and Planning

The optimal operation of biopharmaceutical processes poses a unique set of problems for manufacturing. Although the process is operating in a validated environment, there is still the need to improve productivity and reduce costs. ChemSim is expert in the use of the Intelligen suite of software products -SuperPro® and SchedulePro® - to improve scheduling, determine resource requirements, and reduce bottlenecks.  

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• Facility configuration
• Equipment utilization
• Equipment bottlenecks
• Conflicts among shared equipment/resources such as buffer prep, media prep and CIP skids
• Resource utilization 
• Water consumption, including USP and WFI
• Labor analysis
• Monoclonal Antibody production 

Introduction Articles 

• "Bioprocess Simulation: Taking the Error our of Trial-and-Error," ​Innovations in Pharmaceutical Technology, Winter 2010.
• "Bioprocess Simulations Gain Traction," Genetic Engineering News, Volume 26, Number 16, September 15, 2006  
• "Process simulation and modeling for industrial bioprocessing: tools and techniques," Industrial Biotechnology, 2005
• "Optimizing productivity in multiproduct batch facilities," Genetic Engineering News, Sept 2003.

Recent Presentations 

• "Operating a multiproduct facility: the critical role of process simulation"  BioTalk, Boston, May 2019 

Software Tools

Superpro®, SchedulePro®, Aspen One®, PD-PLUS, ChemCAD, and others.