Balancing the increased productivity in the bioreactor with downstream purification can be challenging. Process simulation is a useful tool to study different production scenarios and help validate initial design concepts. Accurate in-silico models are used to track the ongoing process and to determine opportunities to optimize throughput for increased productivity.
ChemSim creates process models for the production of monoclonal antibodies and other biologics. Production differences, from the use of smaller volume (1000-2000L) disposable bioreactors to large (15,000L) stainless steel bioreactors, require different approaches. ChemSim models equipment scheduling and resource requirements, including buffer and media preparation, logistics and cleaning requirements, and other essential elements of commercial-scale production.
Cost-productive commercial-scale production techniques create specific challenges and the need for targeted solutions. These applications generally operate at a small scale and require single-use technologies. Significant labor resources are required for scale up and there may be wide process variability. Accurately mapping the process at production scale is an essential step to successful and cost-productive commercialization of the process. ChemSim models potential solutions to meet client cost and production goals.
Process modeling in the cultivated meat and seafood industries allows clients to perform conceptual engineering to determine optimal process configurations. ChemSim creates process flow diagrams to perform techno-economic analyses, cell culture scale up, process scheduling, and resource analysis.