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Balancing the increased productivity in the bioreactor with downstream purification can be challenging. Process simulation is a useful tool to study different production scenarios and help validate initial design concepts. Accurate in-silico models are used to track the ongoing process and to determine opportunities to optimize throughput for increased productivity.

Process flowsheet


Monoclonal Antibody

ChemSim creates process models for the production of monoclonal antibodies and other biologics. Production differences, from the use of smaller volume (1000-2000L) disposable bioreactors to large (15,000L) stainless steel bioreactors, require different approaches. ChemSim models equipment scheduling and resource requirements, including buffer and media preparation, logistics and cleaning requirements, and other essential elements of commercial-scale production.

Emerging Applications

Gene Editing

New technologies, such as cell therapy and gene therapy, pose specific challenges for cost-effective commercial-scale production. These applications generally operate at a small scale and require single-use technologies. Significant labor resources are required for scale up and there may be wide process variability. Accurately mapping the process at production scale is an essential step to successful and cost-productive commercialization of the process. ChemSim models potential solutions to meet client cost and production goals.

Cellular Agriculture

Cellular Agriculture

Process modeling in the cultivated meat and seafood industries allows clients to perform conceptual engineering to determine optimal process configurations. ChemSim creates process flow diagrams to perform techno-economic analyses, cell culture scale up, process scheduling, and resource analysis.

Industrial Biotechnology

Process Pipework

ChemSim partners with clients to investigate complex and integrated biochemical operations without the need for extensive experimentation. ChemSim uses process simulation tools to analyze complete processes, not just single unit operations, from initial concept through design and final plant operation. Approaches include creating process flow diagrams, generating material and energy balances, determining equipment sizing, and estimating capital and operating costs.

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